This uncoupling allows the evolution of new genes, both within gene families and also allelic forms of a gene. 這一耦聯允許新基因的形成，不論是在基因家族內還是以某個基因的等位基因形式。
Hepatocarcinogenesis is strongly linked to increases in allelic losses, chromosomal changes,gene mutations, epigenetic alterations and alterations in molecular cellular pathways. 肝癌的形成與等位基因丟失，染色體改變，基因突變，分子細胞通路改變關系密切。